GW-441756

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TrkA inhibitor

Potent and selective inhibitor of NGFR kinase (TrkA, IC₅₀=2 nM). Blocks TrkA-mediated γH2AX production and apoptosis in TrkA-overexpressing cells.

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Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells: E.J. Jung, et al.; Exp. Mol. Med. 40, 276 (2008), Abstract — Full Text

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