Endogenous intestinal guanylyl cyclase activator.
Intestinal guanylate cyclase possesses an extracellular ligand binding domain, a transmembrane domain, an intracellular protein kinase-like region and a cyclase catalytic domain. GC-C is expressed in various mammalian tissues including intestine, adrenal gland, airway epithelial cells, brain, and olfactory and tracheal mucosa.
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