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Guanosine 3′,5′-cyclic Monophosphothioate, Rp-Isomer . sodium salt

ALX-480-072

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PKG inhibitor

Inhibitor of cGMP-dependent protein kinase (PKG) 1α (cGMP antagonist). Resistant against mammalian cyclic nucleotid-dependent phosphodiesterases. No metabolic side effects. Low membrane permeability.

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Product Details

Alternative Name	Rp-cGMPS . Na, cGMPS . Na, Rp-Isomer
Appearance	White to off-white solid.
CAS	86562-09-6
Couple Target	PKG
Couple Type	Inhibitor
Formula	C₁₀H₁₁N₅O₆SP . Na
MW	360.3 . 23.0
Purity	≥98% (HPLC)
Solubility	Soluble in water (125mM), DMSO (2mM), DMF (1mM), methanol (7mM) or PBS, pH 7.4 (125mM).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Nitric oxide mediates activity-dependent change to synaptic excitation during a critical period in Drosophila: C.N.G. Giachello, et al.; Sci. Rep. 11, 20286 (2021), Abstract
Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS: E. Butt, et al.; Br. J. Pharmacol. 116, 3110 (1995), Abstract
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3′,5′- monophosphorothioates: E. Butt, et al.; FEBS Lett. 263, 47 (1990), Abstract

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Guanosine 3′,5′-cyclic Monophosphothioate, Rp-Isomer . sodium salt

ALX-480-072

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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