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GST-π polyclonal antibody

ADI-MSA-102

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The GST superfamily of enzymes play an important role in detoxification of xenobiotics by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. There are four main GST classes; alpha, mu, pi, and tau. GST-P is a member of the pi class of GSTs, and its expression is specifically increased in the early stages of rat hepatocarcinogenesis. Due to its high affinity for glutathione, GST is frequently utilized as an approximately 26 kDa fusion tag for the expression and purification of recombinant proteins.

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GST-π polyclonal antibody Western blot — Western blot analysis of mouse liver tissue extract, probed with GST-p pAb.

ADI-MSA-102 GST-π polyclonal antibody Western Blot Human 1 — Effect of PXR knock down on BZL mediated P-gp, MRP2, CYP3A4 and GSTπ induction.P-gp (panel A), MRP2 (panel B), CYP3A4 (panel C) and GSTπ (panel D) levels were estimated by western blotting in lysates from HepG2 cells transfected either with 100 nM Control siRNA-A (PXR+) or 100 nM PXR siRNA (h) (PXR−) and exposed to BZL (200 µM, 48 h) or vehicle (C). Equal amounts of total protein (7 µg) were loaded in the gels. O.D. from each protein was related to GAPDH O.D. Uniformity of loading and transfer from gel to PVDF membrane was also controlled with Ponceau S. Typical western blot detections from each group are shown at the bottom of bar graphics. The results (% of each control) are expressed as mean ± S.D. (n = 3). *Significantly different from C, p<0.05.

Image collected and cropped by CiteAb under a CC-BY license from the following publication: Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor. PLoS Negl Trop Dis (2012)

Product Details

Alternative Name	GST-P, Glutathione S-transferase P, GSTP1
Application	IHC, WB
Application Notes	Detects a band of ~26kDa by Western blot.
Formulation	Liquid. In PBS, pH 7.2, containing 50% glycerol.
Host	Rabbit
Immunogen	Human placental GST-π.
Purity Detail	Protein A affinity purified.
Recommendation Dilutions/Conditions	Immunohistochemistry (1:500-1:1,000)Western Blot (1:500-1:1,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human, Mouse, Rat
UniProt ID	P09211
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

RiboTag-based RNA profiling uncovers oligodendroglial lineage-specific inflammation in autoimmune encephalomyelitis: implications for pathogenesis: Wang, Y., Ghimire, S., et al.; J. Neuroinflammation 22, 135 (2025), Abstract
Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration: Liu, X., Xin, D. E., et al.; Cell 187, 2465 (2024), Abstract
RiboTag-based RNA-Seq uncovers oligodendroglial lineage-specific inflammation in autoimmune encephalomyelitis: Wang, Y., Ghimire, S., et al.; bioRxiv , (2024), Application(s): IHC
Chronic Changes In Oligodendrocyte Sub-Populations After Middle Cerebral Artery Occlusion in Neonatal Mice: Frazier, A. P., Mitchell, D. N., et al.; bioRxiv , (2023), Application(s): IHC / Reactant(s): Mouse
Sex differences in the neuronal transcriptome and synaptic mitochondrial function in the cerebral cortex of a multiple sclerosis model.: Itoh, N., Itoh, Y., et al.; Front. Neurol. 14, 1268411 (2023), Application(s): IHC, WB, Abstract
Chronic changes in oligodendrocyte sub-populations after middle cerebral artery occlusion in neonatal mice.: Frazier, A. P., Mitchell, D. N., et al.; Glia 71, 1429 (2023), Application(s): IHC / Reactant(s): Mouse, Abstract
Heat shock protein amplification improves cerebellar myelination in the Npc1nih mouse model: J. Gray, et al.; EBioMedicine 86, 104374 (2022), Application(s): IHC-IF, Abstract
Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination.: Wang, J., Yang, L., et al.; J. Neurosci. 42, 8542 (2022), Reactant(s): Mouse, Abstract
The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis.: Kivell, B. M., Luo, D., et al.; Front. Neurol. 12, 782190 (2022), Application(s): IHC / Reactant(s): Mouse, Abstract
Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model.: Wang, Z., Baharani, A., et al.; Clin. Exp. Pharmacol. Physiol. 48, 1090 (2021), Application(s): WB, Abstract

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GST-π polyclonal antibody

ADI-MSA-102

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