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Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.
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RUO – Research Use Only |
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| CAS | 38966-21-1 |
|---|---|
| Couple Type | Inhibitor |
| Purity | ≥98% (TLC) |
| Alternative Name | (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-(3H)-furanone |
|---|---|
| CAS | 7770-78-7 |
| Couple Type | Inhibitor |
| Purity | ≥97% (HPLC) |
| Alternative Name | (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-2(3H)-furanone |
|---|---|
| CAS | 20362-31-6 |
| Couple Type | Inhibitor |
| Purity | ≥95% (HPLC) |
| Alternative Name | EGCG, (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate) |
|---|---|
| CAS | 989-51-5 |
| Couple Type | Inhibitor |
| Purity | ≥98% (HPLC) |