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Grp94 polyclonal antibody

ADI-SPA-851

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Grp94 (Glucose-regulated protein 94) is an abundant resident endoplasmic reticulum (ER) lumenal stress protein, which together with cytosolic Hsp90 belongs to the Hsp90 family of molecular chaperones. Grp94 expression is upregulated by stress conditions such as glucose starvation and heat shock, which promote protein misfolding or unfolding. In addition to a homeostatic role in protein folding and assembly, Grp94 can function in the intracellular trafficking of peptides from the extracellular space to the MHC class I antigen processing pathway of antigen presentation cells.

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This antibody is covered by our Worry-Free Guarantee.

Grp94 polyclonal antibody Immunohistochemistry — Immunohistochemistry analysis of human small intestine tissue stained with Grp94, pAb at 10µg/ml.

Product Details

Alternative Name	Endoplasmin, Tra1, Hsp90B1, Gp96
Application	ICC, IHC (PS), IP, WB
Application Notes	Detects a band of ~94kDa by Western blot.
Formulation	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Gene/Protein Identifier	NP_035761 (RefSeq)
Host	Rabbit
Immunogen	Synthetic peptide corresponding to the sequence near the C-terminus of mouse Grp94.
Purity Detail	Protein A affinity purified.
Recommendation Dilutions/Conditions	Immunoprecipitation (1:80)Western Blot (1:1,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from rabbit serum.
Species Reactivity	Bovine, Human, Mouse, Rat
UniProt ID	P08113
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

CHIP Haploinsufficiency Exacerbates Hepatic Steatosis via Enhanced TXNIP Expression and Endoplasmic Reticulum Stress Responses: J.H. Han, et al.; Antioxidants 12, 458 (2023), Abstract
Charcot-Marie-Tooth-1A and sciatic nerve crush rat models: insights from proteomics: Msheik, Z., Durand, S., et al.; Neural Regen. Res. 18, 1354 (2023), Abstract
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication: Hsu, J. C., Laurent-Rolle, M., et al.; Mol. Cell 82, 1631 (2022), Abstract
Improved skeletal muscle fatigue resistance in experimental autoimmune myositis mice following high-intensity interval training: T. Yamdaa, et al.; Arthritis Res. Ther. 24, 156 (2022), Application(s): WB, Abstract
PD-L1 in circulating exosomes of Merkel cell carcinoma: Zanella, A., Vautrot, V., et al.; Exp. Dermatol. 31, 869 (2022), Abstract
Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool.: Filippone, M. G., Freddi, S., et al.; J. Cell Biol. 221, (2022), Application(s): WB, Abstract
Suppression of ER-stress induction of GRP78 as an anti-neoplastic mechanism of the cardiac glycoside Lanatoside C in pancreatic cancer: Lanatoside C suppresses GRP78 stress inductio: D.P. Ha, et al.; Neoplasia 23, 1213 (2021), Abstract
Endoplasmic reticulum oxidoreductase 1 alpha modulates prostate cancer hallmarks: Cornelius, J., Cavarretta, I., et al.; Transl. Androl. Urol. 10, 1110 (2021), Abstract
Molecular adaptation to calsequestrin 2 (CASQ2) point mutations leading to catecholaminergic polymorphic ventricular tachycardia (CPVT): comparative analysis of R33Q and D307H mutants: G. Valle, et al.; J. Muscle Res. Cell Motil. 41, 251 (2020), Abstract — Full Text
Cellular, Extracellular and Extracellular Vesicular miRNA Profiles of Pre-Ovulatory Follicles Indicate Signaling Disturbances in Polycystic Ovaries.: Fazeli, A., Andronowska, A., et al.; Int. J. Mol. Sci. 21, (2020), Application(s): WB / Reactant(s): Human, Abstract

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Grp94 polyclonal antibody

ADI-SPA-851

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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