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Grp78/BiP polyclonal antibody

ADI-SPA-768

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Grp78 (Glucose Regulated 78kDa Protein), is also known as BiP or Immunoglobulin heavy chain binding protein. It is a stressresponse protein which is induced by agents or conditions that adversely affect endoplasmic reticulum (ER) function. This protein is essential for the proper glycosylation, folding, and assembly of many membrane bound and secreted proteins as well as for maintenance of cell homeostasis and the prevention of apoptosis.

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This antibody is covered by our Worry-Free Guarantee.

Grp78/BiP polyclonal antibody Western blot — Western blot analysis of Grp78, pAb (Prod. No. ADI-SPA-768): Lane 1: MW marker, Lane2: Grp78/BiP (hamster), (recombinant) (Prod. No. ADI-SPP-765), Lane3: Liver (rat), (microsome extract) (Prod. No. ADI-LYT-RM100)

Product Details

Alternative Name	HspA5, Glucose Regulated Protein 78, Hsp70-5, Heat shock protein 70 family
Application	WB
Application Notes	Detects a band of ~78kDa by Western blot.
Formulation	Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
GenBank ID	M14050
Host	Rabbit
Immunogen	Synthetic peptide corresponding to the sequence near the C-terminus of rat Grp78 (BiP). The sequence is completely conserved in mouse and hamster.
Purity Detail	Protein A affinity purified.
Source	Purified from rabbit serum.
Species Reactivity	Bovine, Dog, Fungus, Guinea pig, Hamster, Human, Monkey, Mouse, Rabbit, Rat, Sheep, Xenopus
UniProt ID	P06761
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

ER Stress in ERp57 Knockout Knee Joint Chondrocytes Induces Osteoarthritic Cartilage Degradation and Osteophyte Formation: Y. Rellmann, et al.; Int. J. Mol. Sci. 23, 182 (2022), Application(s): ICC, Abstract
Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway: A. Abdolahi, et al.; J. Physiol. Biochem. 78, 185 (2022), Abstract
Sleep Apnea in Idiopathic Pulmonary Fibrosis: A Molecular Investigation in an Experimental Model of Fibrosis and Intermittent Hypoxia.: Marchant, D., Boncoeur, E., et al.; Life (Basel) 11, (2021), Reactant(s): Mouse, Abstract
Endoplasmic reticulum stress as a novel target to ameliorate epithelial-to-mesenchymal transition and apoptosis of human peritoneal mesothelial cells: H.S. Shin, et al.; Lab. Invest. 95, 1157 (2015), Application(s): Western Blot, Abstract
ERp29, an Endoplasmic Reticulum Secretion Factor Is Involved in the Growth of Breast Tumor Xenografts: S. Mkrtchian, et al.; Mol. Carcinog. 47, 886 (2008), Application(s): WB using human tissue culture, Abstract
Y Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim: A. Samali, et al.; J. Cell. Mol. Med. 12, 2482 (2008), Application(s): WB using rat cell lysates, Abstract
Small heat-shock proteins select DeltaF508-CFTR for endoplasmic reticulum-associated degradation: J. Brodsky, et al.; Mol. Biol. Cell 18, 806 (2007), Application(s): WB using human cell lysates, Abstract
gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation: B. De Strooper, et al.; J. Cell. Sci. 116, 1127 (2003), Application(s): ICC using mouse samples, Abstract
Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild-type SOD1, induces ER stress in COS7 cells and transgenic mice: T. Kato, et al.; Biochem. Biophys. Res. Commun. 303, 496 (2003), Application(s): ICC, WB, IHC using monkey samples, Abstract
Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria: H.G. Wang, et al.; Cancer Res. 63, 1483 (2003), Application(s): WB using human samples, Abstract

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