Growth Hormone mutant (G119R) (chicken), (recombinant)

Somatotropin, GH, GH-N, Growth Hormone 1, Pituitary growth hormone

Chicken recombinant growth hormone G119R mutant did not bind to ovine growth hormone extracellular domain (ECD) and was devoid of any biological activity in FDC-P1 3B9 cells. However, in binding experiments that were carried out using chicken liver membranes, both ovine growth hormone and chicken recombinant growth hormone showed similar IC50 values in competition with 125I-oGH, while the IC50 of chicken recombinant chicken growth hormone G119R mutein was 10-fold higher. These results emphasize the importance of species specificity and indicate the possibility of antagonistic activity of chicken recombinant growth hormone G119R in homologous system.

< 0.1 ng/µg of protein (<1EU/µg)

Lyophilized.

22.3 kDa

> 98.0% as determined by RP-HPLC, Gel filtration and SDS-PAGE Silver Stained gel.

Produced in E. coli.

P08998