Home Shop Granzyme B (human), (recombinant)

Granzyme B (human), (recombinant)

BML-SE238

13 citations

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Granzyme B is a component of the cytolytic granules of cytotoxic T lymphocytes and natural killer cells.

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Product Details

Biological Activity	A serine protease with caspase-like substrate specificity.
Concentration	100 U/µl
Formulation	Liquid. In 50mM TRIS, pH 7.4, 100mM NaCl, 10% glycerol.
MW	25.4 kDa
Purity Detail	Partially purified by single-step affinity chromatography and gel filtration.
Source	Produced in yeast. Recombinant human granzyme B (aa 21-247).
Specific Activity	One unit hydrolyzes 1 pmol/min of Ac-IEPD-pNA (200 µM, Prod. No. BML-P133) at 30°C.
UniProt ID	P10144

Handling & Storage

Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Cell-associated galectin 9 interacts with cytotoxic T cells confers resistance to tumor killing in nasopharyngeal carcinoma through autophagy activation: Kam, N. W., Lau, C. Y., et al.; Cell. Mol. Immunol. 22, 260 (2025), Abstract
CRY1 fuels resistance to T cell-based immunotherapy in NANOGhigh cancers: Kim, T. W., Oh, S. J., et al.; Research Square , (2025)
TRPV1 inhibition sensitizes tumors to PD-1 blockade by reversing resistance to CTL-mediated killing: Son, M. K., Lee, H. J., et al.; Sci. Rep. 15, 20600 (2025), Abstract
Decoding the mechanisms of chimeric antigen receptor (CAR) T cell-mediated killing of tumors: insights from granzyme and Fas inhibition: M. Montalvo, et al.; Cell Death Dis. 15, 109 (2024), Abstract
Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells: A.L. Pourzia, et al.; Cell Death Dis. 14, 267 (2023), Abstract
Apoptosis in mesenchymal stromal cells activates an immunosuppressive secretome predicting clinical response in Crohn’s disease: T.S. Cheung, et al.; Mol. Ther. 31, 3531 (2023), Abstract
LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells: Kim, S., Cho, H., et al.; Autophagy 17, 1978 (2021), Abstract
Stabilization of HDAC1 via TCL1-pAKT-CHFR axis is a key element for NANOG-mediated multi-resistance and stem-like phenotype in immune-edited tumor cells: S.R. Woo, et al.; Biochem. Biophys. Res. Commun. 503, 1812 (2018), Abstract
Measurement of Cellular Immunity to Influenza Vaccination in Rheumatoid Arthritis; Comparison of Three Assays: N. Madar-Balakirski, et al.; J. Vaccines Vaccin. 6, 1000278 (2015), Application(s): Activity Assay, Full Text
Enhanced expression of PD L1 in cervical intraepithelial neoplasia and cervical cancers: L. Mezache, et al.; Mod. Pathol. 28, 1594 (2015), Application(s): Immunohistochemistry, Abstract

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Granzyme B (human), (recombinant)

BML-SE238

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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