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A G protein antagonist which selectively inhibits the activation of Gq by M1 muscarinic cholinergic receptors (mAChR). Not effective in inhibiting M2 mAChR-promoted GTP hydrolysis by Gi. Inhibition is reversible and competitive with respect to receptor binding to G proteins. Also inhibits activation by cholecystokinin receptor in pancreatic acini at 10µM.
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Last modified: May 29, 2024