Gö 6976

BML-EI269

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PKC inhibitor

Very potent protein kinase C (PKC) inhibitor with high selectivity for the PKC isotypes α and β. Inhibits PKCα (IC₅₀=2.3nM) and PKCß1 (IC₅₀=6.2nM) but has no effect on δ, ε or γ isotypes. Potent antagonist of HIV-1 induction.

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Product Details

Alternative Name	12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole
Appearance	Off-white to yellow solid.
CAS	136194-77-9
Couple Target	PKC
Couple Type	Inhibitor
Formula	C₂₄H₁₈N₄O
MW	378.4
Purity	≥95% (HPLC, TLC)
Solubility	Soluble in DMSO (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for at least 3-4 months when stored at -20°C.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin: Zhu, J., Coyne, C. B., et al.; EMBO J. 30, 4838 (2011), Abstract
Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis: P. Xie, et al.; Am. J. Physiol. Renal Physiol. 298, F1393 (2010), Abstract — Full Text
Atypical isoforms of pKc and insulin secretion from pancreatic beta- cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors: T.E. Harris, et al.; BBRC 227, 672 (1996), Abstract
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes: M. Gschwendt, et al.; FEBS Lett. 392, 77 (1996), Abstract
N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions: K. Wenzel-Seifert, et al.; BBRC 200, 1536 (1994), Abstract
Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C: J. Kleinschroth, et al.; Bioorg. Med. Chem. Lett. 3, 1959 (1993)
Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976: G. Martiny-Baron, et al.; J. Biol. Chem. 268, 9194 (1993), Abstract — Full Text
Go 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low- level-producing reservoir cells in vitro: K.O. Qatsha, et al.; PNAS 90, 4674 (1993), Abstract

Last modified: May 29, 2024

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Gö 6976

BML-EI269

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Handling & Storage

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