Glucagon like peptide 2 (human)

Glucagon-like peptide 2 is a 33- or 34-amino acid peptide located at the C-terminus of, and cleaved from, pro-glucagon by prohormone convertase 3 (PC3). GLP-2 is a potent intestinotropic growth factor, the action of which is transduced by G protein-coupled membrane-bound receptors (GLP2-R) found in the gut. GLP-2Rs are also found in the rodent CNS. The main actions of GLP-2 appear to be crypt cell proliferation, inhibition of enterocyte apoptosis, enhancement of nutrient adsorption and certain reparative effects. Applications: antiserum adsorption control; standard or tracer for immunoassay.