Glucagon like peptide 1 (human) (7-36) amide

A predominant cleaved form of pro-glucagon expressed in the intestine. GLP-1 [7-36]amide is promptly released from the gut after oral ingestion of a meal where it slows gastric emptying and exerts a powerful insulinotropic action leading to elevated serum insulin levels. GLP-1 [7-36] amide promotes satiety and reduces food intake in patients with diabetes mellitus type 2 and has been suggested to have therapeutic potential in the treatment of NIDDM. It has been reported that human pancreatic endocrine tumors contain molecular forms of GLP-1 which resemble those expressed in the small intestine, rather than in their tissue of origin.