Glucagon like peptide 1 (human) (1-36) amide

A predominant cleaved form of pro-glucagon found in the pancreas and central nervous system. It has been reported that human pancreatic endocrine tumours contain molecular forms of GLP-1 which resemble those expressed in the small intestine, rather than in their tissue of origin. Within the CNS, GLP-1 powerfully inhibits feeding in fasting rats, an action which is blocked by prior administration of the GLP-1 receptor antagonist exendin [9-39]. This observation led to the suggestion that central GLP-1 is a physiological mediator of satiety and has projected GLP-1 into the obesity control debate. Glucagon-like peptide (GLP) 1 [1-36] also serves as a control peptide for Anti-Glucagon-like Peptide (GLP) 1 (BML-GA1176). Blocks immunoreactivity at 10 nmol per ml diluted antibody.