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Ginkgolide B

BML-L135

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PAF receptor ligand

Most potent member of the ginkgolide family of PAF antagonists. Ginkgolide B accelerates PAF hydrolysis by promoting PAF-AH I α₂ homodimer activity. Inhibits PAF-induced PMNL chemotaxis (IC₅₀=490 nM). Orally effective against PAF-induced bronchospasm.

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Product Details

Alternative Name	BN 52021
Appearance	White crystalline powder.
CAS	15291-77-7
Couple Target	PAF receptor
Couple Type	Ligand
Formula	C₂₀H₂₄O₁₀
MW	424.4
Purity	≥90% (HPLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (2mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit: F. Bonin, et al.; J. Biol. Chem. 279, 52425 (2004), Abstract — Full Text
Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage: G. M. Vercelloti, et al.; Blood 71, 1100 (1988), Abstract — Full Text
Antagonism of the platelet activating factor-induced rise of the intracellular calcium ion concentration of U937 cells: S. G. Ward, et al.; Br. J. Pharmacol. 93, 769 (1988), Abstract — Full Text
Effects of platelet activating factor on the chemotaxis of normodense eosinophils from normal subjects: N. Tamura, et al.; Biochem. Biophys. Res. Commun. 142, 638 (1987), Abstract
Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988: D. Nunez, et al.; Eur. J. Pharmacol. 123, 197 (1986), Abstract
Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig: S. Desquand, et al.; Eur. J. Pharmacol. 127, 83 (1986), Abstract

Last modified: May 29, 2024

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Ginkgolide B

BML-L135

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