Gingerol

BML-CA422

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ATPase activator

Gingerol ([6]-gingerol), a pungent vanilloid isolated from ginger rhizomes (Zingiber officinale), is a novel and selective activator of skeletal and cardiac SR Ca²⁺-ATPase (EC₅₀=4µM). It is a novel cardiotonic agent with antiplatelet activity. It induces apoptosis in HL-60 cells. Acts as an agonist at vanilloid receptors.

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Product Details

Appearance	White to pale yellow oily or waxy solid.
CAS	23513-14-6
Couple Target	ATPase
Couple Type	Activator
Formula	C₁₇H₂₆O₄
MW	294.4
MeltingPoint	31°C
Purity	≥97% (HPLC)
Solubility	Soluble in 100% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Stromal Interaction Molecule 1 Rescues Store-Operated Calcium Entry and Protects NG115-401L Cells Against Cell Death Induced by Endoplasmic Reticulum and Mitochondrial Oxidative Stress: C. Zhang, et al.; Neurochem. Int. 97, 137 (2016), Application(s): Cell culture, Abstract
Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin: S.O. Kim, et al.; Biofactors 21, 27 (2004), Abstract
Gingerols: a novel class of vanilloid receptor (VR1) agonists: V. N. Dedov, et al.; Br. J. Pharmacol. 137, 793 (2002), Abstract — Full Text
Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol: E. Lee, et al.; Cancer Lett. 134, 163 (1998), Abstract
Antiplatelet effect of gingerol isolated from Zingiber officinale: J. H. Guh, et al.; J. Pharm. Pharmacol. 47, 329 (1995), Abstract
Gingerol, a novel cardiotonic agent, activates the Ca2+-pumping ATPase in skeletal and cardiac sarcoplasmic reticulum: M. Kobayashi, et al.; Biochim. Biophys. Acta 903, 96 (1987), Abstract

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Gingerol

BML-CA422

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