Genipin

ALX-350-383

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UCP2 inhibitor

Cell permeable inhibitor of uncoupling protein 2 (UCP2). Increases glucose-stimulated insulin secretion, mitochondrial membrane potential and ATP levels in pancreatic island cells. Induces apoptosis. Protein cross-linking agent. Anti-inflammatory and anti-angiogenic.

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Product Details

Alternative Name	(+)-Genipin, Methyl (1S,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate
Appearance	White to off-white crystalline solid.
CAS	6902-77-8
Couple Target	UCP
Couple Type	Inhibitor
Formula	C₁₁H₁₄O₅
MW	226.2
Purity	≥98% (HPLC)
RTECS	GY5828000
Solubility	Soluble in DMSO (50mg/ml), dimethyl formamide (25mg/ml), 100% ethanol (5mg/ml), methanol or ethyl acetate; insoluble in water.
Source	Isolated from Gardenia jasminoides Ellis.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

In situ formation of silk-gelatin hybrid hydrogels for affinity-based growth factor sequestration and release: J.C. Bragg, et al.; RSC Advances 6, 114353 (2016)
Tissue engineering of ureteral grafts: Preparation of biocompatible crosslinked ureteral scaffolds of porcine origin: H. Koch, et al.; Front. Bioeng. Biotechnol. 3, 89 (2015), Application(s): Cell Culture, Abstract — Full Text
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity: L.E. Parton, et al.; Nature 449, 228 (2007), Abstract
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets: C.Y Zhang, et al.; Cell Metab. 3, 417 (2006), Abstract
Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway: B.C. Kim, et al.; Biochem. Pharmacol. 70, 1398 (2005), Abstract

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Last modified: May 29, 2024

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Genipin

ALX-350-383

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