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Gemcitabine . hydrochloride

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DNA synthesis inhibitor

Deoxycytidine analog with cytotoxic effects. Induces apoptosis and inhibits DNA synthesis.

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Alternative Name	2’-Deoxy-2’,2’-difluorocytidine . HCl, LY-188011 . HCl
Appearance	White to off-white crystalline powder.
CAS	122111-03-9
Formula	C₉H₁₁F₂N₃O₄. HCl
Identity	Determined by IR.
MI	14: 4386
MW	263.2 . 36.5
Purity	≥97.5% (Assay)
RTECS	HA3840000
Solubility	Soluble in water; slightly soluble in methanol; almost insoluble in 100% ethanol or polar organic solvents.
Source	Synthetic.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells: S. Kumar, et al.; Cancer Lett. 413, 82 (2017), Abstract
Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673: A.Z. Andrei, et al.; Cancer Lett. 364, 8 (2015), Application(s): Cell Culture, Abstract
Cellular pharmacology of gemcitabine: E. Mini, et al.; Ann. Oncol. 17, v7 (2006), Abstract — Full Text
Gemcitabine: a cytidine analogue active against solid tumors: Y.F. Hui & J. Reitz; Am. J. Health Syst. Pharm. 54, 162 (1997), Abstract
Gemcitabine: metabolism, mechanisms of action, and self-potentiation: W. Plunkett, et al.; Semin. Oncol. 22, 3 (1995), Abstract
Cellular elimination of 2’,2’-difluorodeoxycytidine 5’-triphosphate: a mechanism of self-potentiation: V. Heinemann, et al.; Cancer Res. 52, 533 (1992), Abstract — Full Text

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