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Geldanamycin-FITC

BML-EI361

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HSP90 inhibitor

A novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for HSP90 inhibitors. May also be used for detection of cell surface HSP90.

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Product Details

Appearance	Purple solid.
Couple Target	HSP90
Couple Type	Inhibitor
Formula	C₅₅H₆₃N₅O₁₃S
MW	1034.2
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (>10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Development of a fluorescence polarization assay for the molecular chaperone Hsp90: J. Kim, et al.; J. Biomol. Screen 9, 375 (2006), Abstract
A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues: L.T. Gooljarsingh, et al.; Proc. Natl. Acad. Sci. USA 103, 7625 (2006), Abstract
Synthesis of novel fluorescent probes for the molecular chaperone Hsp90: L. Llauger-Bufi, et al.; Bioorg. Med. Chem. Lett. 13, 3975 (2003), Abstract

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Geldanamycin-FITC

BML-EI361

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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