GEA 3162

ALX-430-004

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Nitric oxide donor

Water soluble nitric oxide donor and potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). Stimulates cGMP production in platelets, granulocytes and polymorphonuclear leukocytes. Vasodepressant.

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Product Details

Alternative Name	1,2,3,4-Oxatriazolium, 5-amino-3-(3,4-dichlorophenyl)-, chloride
Appearance	White to off-white crystalline solid.
CAS	144575-47-3
Formula	C₇H₄Cl₂N₄O . HCl
Identity	Determined by NMR.
MW	231.0 . 36.5
Purity	≥97% (TLC)
Solubility	Soluble in water, methanol or DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from oxygen. Use fresh solutions.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets: A. Fu, et al.; Cell Rep. 37, 110037 (2021), Abstract
Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes: S. Ljubicic, et al; Cell Rep. 10, 497 (2015), Application(s): Cell Culture, Abstract
GEA3162, a nitric oxide-releasing agent, activates non-store-operated Ca2+ entry and inhibits store-operated Ca2+ entry pathways in neutrophils through thiol oxidation: M.F. Hsu, et al.; Eur. J. Pharmacol. 535, 43 (2006), Abstract
Flow cytometric evaluation of human neutrophil apoptosis during nitric oxide generation in vitro: the role of exogenous antioxidants: Z. Sulowska, et al.; Mediators Inflamm. 2005, 81 (2005), Abstract — Full Text
GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism: E.L. Taylor, et al.; Br. J. Pharmacol. 143, 179 (2004), Abstract
Ca(2+) entry activated by S-nitrosylation. Relationship to store-operated ca(2+) entry: H.T. Ma, et al.; J. Biol. Chem. 274, 35318 (1999), Abstract — Full Text
Pharmacology of mesoionic oxatriazole derivatives in blood, cardiovascular and respiratory systems: T. Corell, et al.; Pol. J. Pharmacol. 46, 553 (1994), Abstract
Mesoionic oxatriazole derivatives-a new group of NO-donors: G. Karup, et al.; Pol. J. Pharmacol. 46, 541 (1994), Abstract
Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein: U. Malo-Ranta, et al.; FEBS Lett. 337, 179 (1994), Abstract
Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions: E. Moilanen, et al.; Br. J. Pharmacol. 109, 852 (1993), Abstract

Last modified: May 29, 2024

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GEA 3162

ALX-430-004

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Handling & Storage

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