GANT61

ALX-270-482

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GLI inhibitor

Inhibitor of Hedgehog (Hh) signalling pathway. Blocks the GLI function which constitutes the final step in the Hh pathway. Interferes with GLI1 DNA binding in living cells. Inhibits cell proliferation of tumor cells in vitro in a GLI-dependent manner. Blocks cell growth in an in vivo xenograft model using human prostate cancer cells.

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Product Details

Alternative Name	NSC 136476, 2,2’-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl]-benzenamine
Appearance	White to off-white solid.
CAS	500579-04-4
Couple Target	GLI
Couple Type	Inhibitor
Formula	C₂₇H₃₅N₅
MW	429.6
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO (5mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy: A. Citarella, et al.; Cancers 15, 1471 (2023), Abstract
Elevated NF-κB/SHh/GLI1 Signature Denotes a Worse Prognosis and Represent a Novel Potential Therapeutic Target in Advanced Prostate Cancer: Vecchiotti, D., Verzella, D., et al.; Cells 11, (2022), Abstract
Tenascin-C predicts poor outcomes for patients with colorectal cancer and drives cancer stemness via Hedgehog signaling pathway: Z. Yang, et al.; Cancer Cell Int. 20, 122 (2020), Abstract — Full Text
Hedgehog-GLI signaling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells: A. Po, et al.; Sci. Rep. 10, 13988 (2020), Abstract — Full Text
A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth: L. Lospinoso Severini, et al.; Cancers (Basel) 11, 1518 (2019), Abstract
Myelination of Neuronal Cell Bodies when Myelin Supply Exceeds Axonal Demand: Almeida, R. G., Pan, S., et al.; Curr. Biol. 28, 1296 (2018), Abstract
Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma: A. Po, et al.; Oncogene 36, 4641 (2017), Application(s): Cell Viability Assay w. A549, H1437, and H1734 cells, Abstract — Full Text
Targeting GLI1 Suppresses Cell Growth and Enhances Chemosensitivity in CD34+ Enriched Acute Myeloid Leukemia Progenitor Cells: Long, B., Wang, L. X., et al.; Cell. Physiol. Biochem. 38, 1288 (2016), Abstract
p,p’-Dichlorodiphenyltrichloroethane inhibits the apoptosis of colorectal adenocarcinoma DLD1 cells through PI3K/AKT and Hedgehog/Gli1 signaling pathways: L. Song, et al.; Toxicol. Res. 4, 1214 (2015), Application(s): Cell culture
Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination: J. Samanta, et al.; Nature 528, 448 (2015), Application(s): Mice cell culture, Abstract

Last modified: May 29, 2024

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GANT61

ALX-270-482

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