Ganglioside GT1b . trisodium salt (bovine brain)

• Highly pure Ganglioside GQ1b isolated from bovine brain
• Used for the differentiation of a variety of cells

Gangliosides consist of a ceramide moiety, an oligosaccharide head group, and one or more sialic acids. They are involved in a variety of cellular functions acting as cell adhesion receptors and immunological receptors via the binding of lectins; contributing to cell differentiation, cell signaling, and oncogenesis; participating in myelin stability and nerve regeneration; and operating as an entry point for toxins and viruses. Ganglioside GT1b consists of a tetra-saccharide core with two sialic acid on the internal galactose and an extra sialic acid on the non-reducing terminal galactose. Ganglioside GT1b prevents neurotoxicity of glutamate on neuronal cells and binds to the neurotoxins Botulinum Toxin serotype A (BTxA), BTxA heavy chain, and Tetanus Toxin with respective IC50 values of 11, 0.74, and 7.2 µM. Treatment of human PBMC with Ganglioside GT1b is associated with a decrease in IgA, IgG, IgM, IL-6, and IL-10 levels.