Ganglioside GQ1b . tetrasodium salt (bovine brain)

• Highly pure Ganglioside GQ1b isolated from bovine brain
• Used for the differentiation of a variety of cells

Gangliosides consist of a ceramide moiety, an oligosaccharide head group, and one or more sialic acids. They are involved in a variety of cellular functions acting as cell adhesion receptors and immunological receptors via the binding of lectins; contributing to cell differentiation, cell signaling, and oncogenesis; participating in myelin stability and nerve regeneration; and operating as an entry point for toxins and viruses. Ganglioside GQ1b consists of a tetra-saccharide core with two sialic acid on the internal galactose and two sialic acid on the non-reducing terminal galactose. Ganglioside GQ1b promotes the differentiation of human neuroblastoma cells, murine embryonic stem cells via the activation of the ERK1/2 pathway, and murine keratinocytes via phosphoinositide turnover.