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Ganglioside GM3 . sodium salt (bovine brain)

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The major ganglioside of the extra-nervous system. Inhibits growth of epidermal cells.

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Alternative Name	GM3 . Na (bovine brain), Monosialoganglioside GM3 . Na (bovine brain)
Appearance	Lyophilized.
CAS	54827-14-4
Formula	C₅₉H₁₀₇N₂O₂₁ . Na
MW	1180.5 . 23.0 (calculated on sphingosine C18:1 and stearic acid)
Purity	≥98% (TLC)
Sequence	[II³Neu5AcLacCer] [α-Neu5Ac-(2→3)]-β-Gal(1→4)-β-Glc-(1→1′)-Cer]
Solubility	Soluble in chlorform/methanol (2:1).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells: S. Watanabe, et al.; Neurosci. Lett. 517, 140 (2012), Abstract
Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor: E.G. Bremer, et al.; J. Biol. Chem. 261, 2434 (1986), Abstract — Full Text
Gangliosides: H. Wiegandt; New Comprehensive Biochemistry: Glycolipids 10, 199 (1985), (Book chapter)

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