Home Shop Ganglioside GD3 . disodium salt (bovine buttermilk)

Ganglioside GD3 . disodium salt (bovine buttermilk)

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Induces mitochondrial permeability transition (MPT) without requiring elevated Ca²⁺ levels and thus triggers Fas-mediated apoptosis.

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Alternative Name	Disialoganglioside GD3 . 2Na (bovine buttermilk), GD3 . 2Na (bovine buttermilk)
Appearance	Lyophilized.
CAS	62010-37-1
Formula	C₇₀H₁₂₃N₃O₂₉ . 2Na
MW	1470.8 . 46.0 (calculated on sphingosine C18:1 and stearic acid)
Purity	≥98% (TLC)
Sequence	[Il³(Neu5Ac)₂LacCer] [[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1′)-Cer]
Solubility	Soluble in chloroform/methanol, 2:1
Source	Bovine buttermilk

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells: S. Watanabe, et al.; Neurosci. Lett. 517, 140 (2012), Abstract
Ganglioside GD3 and its mimetics induce cytochrome c release from mitochondria: Y. Inoki, et al.; BBRC 276, 1210 (2000), Abstract
Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition: B.S. Kristal & A.M. Brown; J. Biol. Chem. 274, 23169 (1999), Abstract — Full Text
Lipid signaling in CD95-mediated apoptosis: F. Malisan & R. Testi; FEBS Lett 452, 100 (1999), (Review), Abstract
Ganglioside GD3, the mitochondrial permeability transition, and apoptosis: B.S. Kristal & A.M. Brown; Ann. NY Acad. Sci. 893, 321 (1999), (Review), Abstract

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