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Ganglioside GD1a . disodium salt (bovine brain)

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PKC inhibitor

Differentiation marker for cell growth. Protein kinase C (PKC) inhibitor. The major ganglioside of the nervous system.

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Alternative Name	Disialoganglioside GD1a . 2Na (bovine brain), GD1a . 2Na (bovine brain)
Appearance	Lyophilized.
CAS	12707-58-3
Couple Target	PKC
Couple Type	Inhibitor
Formula	C₈₄H₁₄₆N₄O₃₉ . 2Na
MW	1836.1 . 46.0 (calculated on sphingosine C18:1 and stearic acid)
Purity	≥98% (TLC)
Sequence	[II³(Neu5Ac),IV³(Neu5Ac)GgOse₄Cer] [[α-Neu5Ac-(2→3)]-β-Gal-(1→3)-β-GalNAc-(1→4)-[α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1′)-Cer]
Solubility	Soluble in chloroform/methanol/DI water, 2:1:0.1

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Anti-inflammatory role of GM1 and other gangliosides on microglia: D. Galleguillos, et al.; J. Neuroinflammation 19, 9 (2022), Abstract — Full Text
Bifunctional hetero di-disc for broad-spectrum influenza neutralization: S. Moon, et al.; Nanomedicine 44, 102587 (2022), Abstract
Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome: Kong, B., Moon, S., et al.; Nat. Commun. 10, 185 (2019), Abstract
Ganglioside GD1a suppresses LPS-induced pro-inflammatory cytokines in RAW264.7 macrophages by reducing MAPKs and NF-κB signaling pathways through TLR4: Y. Wang, et al.; Int. Immunopharmacol. 28, 136 (2015), Application(s): Cell Culture, Abstract
Chromatographic Separation of Human Brain Gangliosides: L. Svennerholm; J. Neurochem. 10, 613 (1963), Abstract

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