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Gambogic acid

BML-AP305

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Bcl-2 inhibitor, Bax activator

Gambogic Acid is a natural product isolated from Garcinia Hurburyi. It induces apoptosis in several tumor cell lines including T47D breast cancer cells and MGC-803 human gastric carcinoma cells but not in normal cells. Apoptosis induction proceeds via upregulation of bax and inhibition of bcl-2 expression.The target of gambogic acid has been identified as the transferrin receptor.

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Product Details

Appearance	Yellow-orange solid
CAS	2752-65-0
Couple Target	Bax, Bcl-2
Couple Type	Activator, Inhibitor
Formula	C₃₈H₄₄O₈
MW	628.8
Purity	≥95% (TLC)
Solubility	Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml)

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid: S. Kasibhatla, et al.; Proc. Natl. Acad. Sci. 102, 12095 (2005), Abstract — Full Text
Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay: H.-Z. Zhang, et al.; Bioorg. Med. Chem. 12, 309 (2004), Abstract
Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells: L. Zhao, et al.; Biol. Pharm. Bull. 27, 998 (2004), Abstract

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Gambogic acid

BML-AP305

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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