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Galiellalactone

ALX-350-336

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STAT3 inhibitor

Originally isolated from Galiella rufa as a plant growth regulator. Inhibits IL-6 mediated signal transduction by blocking the binding of the activated STAT3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation site of the STAT3 transcription factor.

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Product Details

Appearance	White to light tan solid.
CAS	133613-71-5
Couple Target	STAT
Couple Type	Inhibitor
Formula	C₁₁H₁₄O₃
Formulation	Lyophilized.
MW	194.2
Purity	≥95% (HPLC)
Solubility	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
Source	Isolated from an unidentified fungus, MST-FP1889.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Immune Regulation of Interleukin-27 in Malignant Pleural Effusion: S. Li, et al.; Chin. Med. J. (Engl) 128, 1932 (2015), Abstract — Full Text
Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3: R. Hellsten, et al.; Prostate 68, 269 (2008), Abstract
Synthesis of (-)-galiellalactone: M. Johansson and O. Sterner; J. Antibiot. (Tokyo) 55, 663 (2002), Abstract
Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities: B. Kopcke, et al.; J. Antibiot. (Tokyo) 55, 36 (2002), Abstract
Galiellalactone and its biogenetic precursors as chemotaxonomic markers of the Sarcosomataceae (Ascomycota): B. Kopcke, et al.; Phytochemistry 60, 709 (2002), Abstract
Inhibition of interleukin-6 signaling by galiellalactone: M. Weidler, et al.; FEBS Lett. 484, 1 (2000), Abstract
Screening of basidiomycetes and ascomycetes for plant regulating substances: R. Hautzel and H. Anke; Z. Naturforsch. 45c, 1094 (1990)

Last modified: May 29, 2024

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Galiellalactone

ALX-350-336

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