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Galanthamine . hydrobromide

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Acetylcholine esterase inhibitor

Specific, competitive and reversible acetylcholinesterase inhibitor. Alzheimer’s disease therapeutic.

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Alternative Name	Galantamine, Nivalin
Appearance	White to off-white crystalline solid.
CAS	1953-04-4
Couple Target	Acetylcholine esterase
Couple Type	Inhibitor
Formula	C₁₇H₂₁NO₃ . HBr
MI	14: 4340
MW	287.4 . 80.9
Purity	≥98% (HPLC)
RTECS	DF8075000
Solubility	Soluble in DMSO (10mg/ml) or 100% ethanol (4mg/ml); sparingly soluble in water.

Use/Stability	As indicated on product label or CoA when stored as recommended. Solutions are stable for up to 3 months when stored at -20°C.
Handling	Protect from moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Myomesin is part of an integrity pathway that responds to sarcomere damage and disease: Prill, K., Carlisle, C., et al.; PLoS One 14, e0224206 (2019), Abstract
Xirp Proteins Mark Injured Skeletal Muscle in Zebrafish: C. Otten, et al.; PLoS One 7, e31041 (2012), Abstract — Full Text
Galanthamine from snowdrop-the development of a modern drug against Alzheimer’s disease from local Caucasian knowledge.: M. Heinrich & H. Lee Teoh; J. Ethnopharmacol 92, 147 (2004), Abstract
Acetylcholinesterase inhibitors: novel activities of old molecules.: M. Racchi, et al.; Pharmacol. Res. 50, 441 (2004), Abstract
Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats: P. Chopin & M. Briley; Psychopharmacology 106, 26 (1992), Abstract
Galanthamine treatment in Alzheimer’s disease: P. Dal-Bianco, et al.; J. Neural. Transm. Suppl. 33, 59 (1991), Abstract
Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine: T. Thomsen et al.; Eur. J. Clin. Chem. Clin. Biochem. 29, 487 (1991), Abstract

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