Home Shop Fusicoccin

Fusicoccin

BML-EI334

Datasheet
Manual
SDS
CofA

Already have an account?

Plant H⁺-ATPase activator

Phytotoxin used in plant research

Fusicoccin is a diterpene glucoside with numerous effects. Fusicoccin induces H⁺extrusion from plant cells by 14-3-3-dependent activation of the plasma membrane H⁺-ATPase. Fusicoccin induces translocation of 14-3-3 proteins from the cytosol to the membrane and causes a dramatic increase in cytosolic 14-3-3. Fusicoccin stimulates release of cytochrome c from mitochondria, cell enlargement, ion uptake, seed germination, opening the stomata, etc. Fusicoccin markedly reduces the ability of the cells to scavenge H₂O₂. Fusicoccin has been demonstrated to cause randomization of asymmetry of the left-right axis (heterotaxia) in Xenopus embryos.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	NSC 113500
Appearance	Solid.
CAS	20108-30-9
Couple Target	14-3-3, ATPase
Couple Type	Activator, Inhibitor
Formula	C₃₆H₅₆O₁₂
MW	680.8
Purity	≥90% (HPLC)
Solubility	Soluble in DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Fragment-Based Interrogation of the 14-3-3/TAZ Protein-Protein Interaction: B. Andlovic, et al.; Biochemistry 63, 2196 (2024), Abstract
Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues: Vickery, H. R., Virta, J. M., et al.; SLAS Discov. 29, 100165 (2024), Abstract
Stabilization of 14-3-3 protein-protein interactions with Fusicoccin-A decreases alpha-synuclein dependent cell-autonomous death in neuronal and mouse models: Vinueza-Gavilanes, R., Bravo-González, J. J., et al.; Neurobiol. Dis. 183, 106166 (2023), Abstract
Biphasic control of cell expansion by auxin coordinates etiolated seedling development: M. Du, et al.; Sci. Adv. 8, eabj1570 (2022), Abstract — Full Text
Plasma membrane H+-ATPases promote TORC1 activation in plant suspension cells: C. Primo, et al.; iScience 25, 104238 (2022), Abstract — Full Text
Green Tea Catechins, (-)-Catechin Gallate, and (-)-Gallocatechin Gallate are Potent Inhibitors of ABA-Induced Stomatal Closure: K. Sato, et al.; Adv. Sci. 9, e2201403 (2022), Abstract
Auxin signaling-mediated apoplastic pH modification functions in petal conical cell shaping: X. Dang, et al.; Cell Rep. 30, 3904 (2020), Abstract
Inhibition of catalase activity as an early response of Arabidopsis thaliana cultured cells to the phytotoxin fusicoccin: N. Beffagna & I. Lutzu; J. Exp. Bot. 58, 4183 (2007), Abstract
Fusicoccin affects cytochrome c leakage and cytosolic 14-3-3 accumulation independent of H-ATPase activation: M. Malerba, et al.; Physiol. Plant 120, 386 (2004), Abstract
Fusicoccin signaling reveals 14-3-3 protein function as a novel step in left-right patterning during amphibian embryogenesis: T.D. Bunney, et al.; Development 130, 4847 (2003), Abstract