Home Shop Furin convertase substrate (fluorogenic)

Furin convertase substrate (fluorogenic)

ALX-260-040

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Fluorogenic substrate for furin/SPC1/PACE/PCSK3 and other subtilisin/kexin-like proprotein convertases such as Kex2, SPC2/PC2/PCSK2, SPC3/PCSK1, PACE4/SPC4/PCSK6, SPC5/PC4/PCSK4, SPC6/PC5/PC6/PCSK5, and SPC7/LPC/PC7/PC8/PCSK7. Can be used on live cells. Ex: 360-380 nm, Em: 440-460 nm.

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Product Details

Alternative Name	Boc-RVRR-AMC, Boc-Arg-Val-Arg-Arg-AMC
Appearance	White to off-white powder.
CAS	136132-77-9
Formula	C₃₈H₆₂N₁₄O₈
MW	843.0
Purity	≥95% (HPLC; TLC)
Sequence	Boc-Arg-Val-Arg-Arg-AMC (AMC=7-Amino-4-methylcoumarin)
Solubility	Soluble in water (10mg/ml) or DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion: P. Jaaks, et al.; PLoS One 11, e0161396 (2016), Abstract — Full Text
Fluid shear stress promotes proprotein convertase-dependent activation of MT1-MMP: H. Kang, et al.; Biochem. Biophys. Res. Commun. 460, 596 (2015), Application(s): Fluorescence Microscopy, Abstract
Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection: L. Cruz, et al.; Viruses 7, 5813 (2015), Application(s): In vitro Furin enzyme-treatment of fluorogenic furin assay, Abstract — Full Text
A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40?kDa vasculostatin from tumor suppressor BAI1: S.M. Cork, et al.; Oncogene 31, 5144 (2012), Abstract — Full Text
Production, purification, and characterization of recombinant prohormone convertase 5 from baculovirus-infected insect cells: B.M. Cain, et al.; Protein Expr. Purif. 24, 227 (2002), Abstract
Molecular cloning of kpcA gene encoding a Kex2p-like endoprotease from Aspergillus nidulans: B.K. Kwon, et al.; Mol. Cells 12, 142 (2001), Abstract
Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides: D.J. Krysan, et al.; J. Biol. Chem. 274, 23229 (1999), Abstract
Enzymic characterization in vitro of recombinant proprotein convertase PC4: A. Basak, et al.; Biochem. J. 343, 29 (1999), Abstract
PACE4: a subtilisin-like endoprotease with unique properties: R.E. Mains, et al.; Biochem. J. 321, 587 (1997), Abstract
In vitro characterization of the novel proprotein convertase PC7: J.S. Munzer, et al.; J. Biol. Chem. 272, 19672 (1997), Abstract

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Furin convertase substrate (fluorogenic)

ALX-260-040

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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