Home Shop Furin convertase inhibitor (chloromethylketone)

Furin convertase inhibitor (chloromethylketone)

ALX-260-022

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Highly specific, potent, irreversible, and cell-permeable competitive inhibitor of proprotein convertases.

Highly specific, potent, irreversible, and cell-permeable competitive inhibitor of proprotein convertases: furin/SPC1 (K_i~1nM), SPC2/PC2 (K_i=0.36nM), SPC3/PC1/PC3(K_i=2.0nM), SPC4/PACE4 (K_i=3.6nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (K_i=0.12nM). Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent. In addition, it inhibits furin-dependent pro-MMP-2 activation in various cell lines, including U87 and HT1080 cells. Typical concentration range used in tissue culture is 25-100µM.

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Product Details

Alternative Name	Decanoyl-Arg-Val-Lys-Arg-chloromethylketone, Dec-RVKR-CMK, TACE inhibitor
Appearance	White to off-white powder.
Formula	C₃₄H₆₆N₁₁O₅Cl . 3TFA
MW	744.3 . 342.1
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO, methanol or water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis: K.A. Dowd, et al.; PNAS 120, e2218899120 (2023), Abstract
Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants: Wang, H. I., Chuang, Z. S., et al.; Int. J. Mol. Sci. 22, (2021), Abstract
Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry: Y. Wan, et al.; J. Virol. 94, e02015 (2020), Application(s): Treatment of cell culture, Abstract — Full Text
Cleavage activates Dispatched for Sonic Hedgehog ligand release: D.P. Stewart, et al.; Elife 7, e31678 (2018), Abstract — Full Text
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity: J. Li, et al.; Cell 168, 86 (2017), Abstract
Enhancing dengue virus maturation using a stable furin over-expressing cell line: S. Mukherjee, et al.; Virology 497, 33 (2016), Application(s): Cell culture, reduce the efficiency of prM cleavage in virus preparations, Abstract
Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor: M. de Santi, et al.; Cell. Oncol. (Dordr.) 39, 149 (2016), Application(s): Treatment of HEK293 cells, Abstract
Secretome Signature Identifies ADAM17 as Novel Target for Radiosensitization of Non-Small Cell Lung Cancer: A. Sharma, et al.; Clin. Cancer. Res. 22, 4428 (2016), Application(s): Cell culture, Abstract — Full Text
Secreted factors from adipose tissue-derived mesenchymal stem cells suppress oxygen/glucose deprivation-induced cardiomyocyte cell death via furin/PCSK-like enzyme activity: Y. Tachida, et al.; Biochem. Biophys. Rep. 7, 266 (2016), Application(s): Furin/PCSK-like enzyme activity in synthetic substrate, Abstract — Full Text
PCSK6-mediated corin activation is essential for normal blood pressure: S. Chen, et al.; Nat. Med. 21, 1048 (2015), Application(s): Trypsin digestion, Abstract