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Fumonisin B₂

BML-SL219

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Ceramide synthase inhibitor

Mycotoxin, structurally similar to fumonisin B₁ (Prod. No. BML-SL220). Found as contaminant mostly in corn silage; was detected recently for the first time in the industrially important Aspergillus niger. Induces cancer. Inducer of apoptosis. Inhibits sphinganine N-acyltransferase (ceramide synthase) at IC₅₀ = 0.1µM. Inhibits de novo sphingolipid biosynthesis.

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Product Details

Appearance	Off-white solid.
CAS	116355-84-1
Couple Target	Ceramide synthase, Sphinganine N-acyltransferase
Couple Type	Inhibitor
Formula	C₃₄H₅₉NO₁₄
MI	14: 4289 (Fumonisin B₁)
MW	705.8
Purity	≥98% (TLC)
RTECS	TZ8335000
Solubility	Soluble in water (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res. 54, 87 (2015), Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis, Full Text
Fumonisin B2 Production by Aspergillus niger: J.C. Frisvad, et al.; J. Agric. Food Chem. 55, 9727 (2007), Abstract
Liquid chromatographic determination of fumonisins B1, B2, and B3 in corn silage: E.K. Kim, et al.; J. Agric. Food Chem. 52, 196 (2004), Abstract
Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells: H. Wang, et al.; PNAS 93, 3461 (1996), Abstract
Fumonisins: fungal toxins that shed light on sphingolipid function: A.H. Merrill, et al.; Trends Cell Biol 6, 218 (1996), Abstract
Liquid chromatographic determination of the mycotoxin fumonisin B2 in physiological samples: G.S. Shephard, et al.; J. Chromatogr. A 692, 39 (1995), Abstract
Biological activities of fumonisins, mycotoxins from Fusarium moniliforme, in jimsonweed (Datura stramonium L.) and mammalian cell cultures: H.K. Abbas, et al.; Toxicon 31, 345 (1993), Abstract
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme: E. Wang, et al.; J. Biol. Chem. 266, 22 (1991), Abstract

Last modified: May 29, 2024

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Fumonisin B₂

BML-SL219

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