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Fumagillin

BML-CT100

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Methionine aminopeptidase 2 inhibitor

Inhibitor of angiogenesis and endothelial cell proliferation. Specific inhibitor of methionine aminopeptidase type II (MetAP-II) by covalently modifying a conserved active-site histidine. Precursor to TNP-470. Exhibits antitumor activity in estrogen-induced pituitary adenoma. Antineoplastic. Anti-infective.

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Product Details

Alternative Name	Fumidil B, Fumadil B, TNP-470
Appearance	Off-white to light yellow solid.
CAS	23110-15-8
Couple Target	Aminopeptidase
Couple Type	Inhibitor
Formula	C₂₆H₃₄O₇
MI	14: 4286
MW	458.5
Purity	≥95% (TLC)
Solubility	Soluble in DMSO (25mg/ml) or diluted aqueous bases; slightly soluble in methanol or other alcoholic solvents; insoluble in water.
Source	Isolated from Aspergillus fumigatus.
Technical Info / Product Notes	Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solutions with pH >9.0 or pH <5.0.
Handling	Protect from light and oxygen. Keep under inert gas.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements: Chen, C. Z., Kulakova, L., et al.; Antimicrob. Agents Chemother. 55, 667 (2011), Abstract
FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470): G.J. Chen, et al.; J. Cell Biochem. 101, 1492 (2007), Abstract
Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors: B. Lefkove, et al.; Expert Rev. Anti Infect. Ther. 5, 573 (2007), Review, Abstract
Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis: I.S. Sheen, et al.; World J. Gastroenterol. 11, 771 (2005), Abstract
Whirling disease of salmonid fish: life cycle, biology, and disease: M.A. Gilbert & W.O. Granath, Jr.; J. Parasitol. 89, 658 (2003), Abstract
Fumagillin treatment of intestinal microsporidiosis: J.M. Molina, et al.; N. Engl. J. Med. 346, 1963 (2002), Abstract
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2: E.C. Griffith, et al.; PNAS 95, 15183 (1998), Abstract
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase: W.T. Lowther, et al.; PNAS 95, 12153 (1998), Abstract — Full Text
The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2: N. Sin, et al.; PNAS 94, 6099 (1997), Abstract — Full Text
Inhibitory effects of fumagillin and its analogue TNP-470 on the function, morphology and angiogenesis of an oestrogen-induced prolactinoma in Fischer 344 rats: H. Stepien, et al.; J. Endocrinol. 150, 99 (1996), Abstract

Related Products

MetAP2 (human), (recombinant) (HA-tag)

BML-SE569

Alternative Name	Methionine aminopeptidase 2, p67eIF2, Eukaryotic initiation factor 2-associated protein
Purity	≥95% (SDS-PAGE)
Source	Produced in insect cells. Recombinant, full-length (aa 1-478) methionine aminopeptidase 2 with an N-terminal hemagglutinin (HA) tag (YPYDVPDYA), cloned from human cDNA. Produced in a baculovirus expression system.

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Fumagillin

BML-CT100

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