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FTY-720 . HCl

BML-SL233

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S1P receptor ligand

Novel immune modulator that alters migration and homing of lymphocytes. Acts as a potent agonist of sphingosine 1-phosphate receptors (S1P) after phosphorylation by sphingosine kinase. Also inhibits cytosolic phospholipase A₂ independently of sphingosine 1-phosphate receptors.

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Product Details

Alternative Name	2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol . HCl, Fingolimod . HCl
Appearance	White solid.
CAS	162359-56-0
Couple Target	Phospholipase, PLA, S1P receptor
Couple Type	Ligand
Formula	C₁₉H₃₃NO₂ . HCl
Identity	Determined by NMR.
MW	307.4 . 36.5
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (10mg/ml), 100% ethanol or dimethyl formamide.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen: He, K., Xiao, H., et al.; Nat. Immunol. 25, 2124 (2024), Abstract
Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants: I. Pirozzolo, et al.; J. Clin. Invest. 132, e153403 (2022), Abstract
Resident T cells orchestrate adipose tissue remodeling in a site peripheral to infection: Kabat, A. M., Hackl, A., et al.; bioRxiv , (2022)
All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages: Rao, E., Hou, Y., et al.; Sci. Immunol. 6, (2021), Abstract
Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation: Chen, M., Qiao, G., et al.; Nat. Commun. 11, 1821 (2020), Abstract
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy: Siddiqui, I., Schaeuble, K., et al.; Immunity 50, 195 (2019), Abstract
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment: Spranger, S., Koblish, H. K., et al.; J. Immunother. Cancer 2, 3 (2014), Abstract
The Sphingosine 1-Phosphate Receptor Agonist FTY720 Potently Inhibits Regulatory T Cell Proliferation In Vitro and In Vivo: A.M. Wolf, et al.; J. Immunol. 183, 3751 (2009), Abstract
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia: P. Neviani, et al.; J. Clin. Invest. 117, 2408 (2007), Abstract — Full Text
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors: S.G. Payne, et al.; Blood 109, 1077 (2007), Abstract

Last modified: May 29, 2024

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FTY-720 . HCl

BML-SL233

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