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Fostriecin

ALX-380-065

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Antitumor antibiotic

Antitumor antibiotic. Catalytic inhibitor of topoisomerase II. Strong protein phosphatase 2A (PP2A) inhibitor (IC₅₀=3.2nM). Weak inhibitor for PP1 (IC₅₀=131µM). No apparent effect on PP2B. The binding site for fostriecin on PP2A is different from that of okadaic acid (see Prod. No. ALX-350-003).

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Product Details

Alternative Name	Phosphotrienin, CI-920
Appearance	Colorless solid.
CAS	87860-39-7
Couple Target	Serine/threonine-protein phosphatase, Topoisomerase
Couple Type	Inhibitor
Formula	C₁₉H₂₆O₉PNa
MW	452.4
Purity	≥98% (HPLC)
RTECS	UQ0600000
Solubility	Soluble in water (50mg/ml), methanol (10mg/ml) or 100% ethanol (10mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year when stored at -20°C. Use fresh solution.
Handling	Protect from light. Packaged under inert gas. Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint: Foss, K. M., Robeson, A. C., et al.; Cell Cycle 15, 225 (2015), Abstract
Fostriecin: chemistry and biology: D.S. Lewy, et al.; Curr. Med. Chem. 9, 2005 (2002), Abstract
Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin: R.S. de Jong, et al.; Br. J. Cancer 79, 882 (1999), Abstract
Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia: C. Weinbrenner, et al.; Circulation 98, 899 (1998), Abstract
Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A: A.H. Walsh, et al.; FEBS Lett. 416, 230 (1997), Abstract
Fostriecin: a review of the preclinical data: R.S. de Jong, et al.; Anticancer Drugs 8, 413 (1997), Abstract
Antitumor drug fostriecin inhibits the mitotic entry checkpoint and protein phosphatases 1 and 2A: M. Roberge, et al.; Cancer Res. 54, 6115 (1994), Abstract
The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents: W. Gorczyca, et al.; Cancer Res. 53, 3186 (1993), Abstract
Induction of DNA strand breaks associated with apoptosis during treatment of leukemias: W. Gorczyca, et al.; Leukemia 7, 659 (1993), Abstract
Comparison of effects of fostriecin, novobiocin, and camptothecin, inhibitors of DNA topoisomerases, on DNA replication and repair in human cells: C.M. Gedik & A.R. Collins; Nucl. Acids Res. 18, 1007 (1990), Abstract

Related Products

Okadaic acid (high purity)

ALX-350-003

Inhibitor of PP1 and PP2A

65 citations

Alternative Name	Halochondrine A, 9,10-Deepithio-9,10-didehydroacanthifolicin
CAS	78111-17-8
Couple Type	Inhibitor
Purity	≥98% (HPLC, TLC)

ALX-350-003-M001 — 1 mg

$1,836.00

Okadaic acid (high purity) quantity
ALX-350-003-C025 — 25 µg

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Okadaic acid (high purity) quantity
ALX-350-003-C050 — 50 µg

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Okadaic acid (high purity) quantity
ALX-350-003-C100 — 100 µg

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Okadaic acid (high purity) quantity

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Fostriecin

ALX-380-065

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