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- Cell-permeable, potent, reversile, and rapid activator of adenylate cyclase
- Compound used to study the role of cAMP as secondary messenger
- Highly cited
Forskolin is naturally produced by the Coleus plant, Coleus forskohlii. Forskolin activates adenylate cyclase by directly interacting with the catalytic unit of the enzyme leading to an increase in the intracellular concentration of cAMP. Forskolin is a widely used tool for the investigation of the role of cAMP as a second messenger with a broad range of potential therapeutic applications. Forskolin is a ionotropic agent and vasodilator. Forskolin also reduces platelet aggregation in a dose-dependent manner, inhibits ion channels by a mechanism that does not involve cAMP, inhibits nicotinic acetylcholine receptors and induces neuronal differentiation in stem cells and several neuroblastoma.
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| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Alternative Name | Cyclic AMP . Na, cAMP . Na |
|---|---|
| CAS | 37839-81-9 |
| Couple Type | Activator |
| Purity | ≥98% (HPLC) |
Direct cAMP ELISA kit
ADI-900-066A
Most sensitive (0.006 pmol/ml) colorimetric kit for intracellular cAMP quantification.
| Application | Colorimetric detection, ELISA |
|---|---|
| Assay Time | 3 hours |
| Sensitivity | Non-acetylated: 1.18 pmol/ml (range 0.78 – 200 pmol/ml)Acetylated: 0.006 pmol/ml (range 0.078 – 20 pmol/ml) |
| Species Reactivity | Species independent |
cAMP ELISA kit
ADI-900-067A
Most sensitive (0.027 pmol/ml) colorimetric kit for extracellular cAMP quantification.
| Application | Colorimetric detection, ELISA |
|---|---|
| Assay Time | 3 hours |
| Sensitivity | Non-acetylated: 0.49 pmol/ml (range 0.78 – 200 pmol/ml)Acetylated: 0.027 pmol/ml (range 0.078 – 20 pmol/ml) |
| Species Reactivity | Species independent |
cAMP complete ELISA kit
ADI-900-163A
Most sensitive (0.006 pmol/ml and 0.027 pmol/ml) and complete colorimetric kit for intra- and extracellular cAMP quantification.
| Application | Colorimetric detection, ELISA |
|---|---|
| Assay Time | 3 hours |
| Sensitivity | Non-acetylated: 0.49 pmol/ml (assay buffer) / 1.18 pmol/ml (HCl) (range (non-acetylated) 0.78 – 200 pmol/ml)Acetlylated: 0.027 pmol/ml (assay buffer) / 0.006 pmol/ml (HCl) (range (acetylated) 0.078 – 20 pmol/ml) |
| Species Reactivity | Species independent |