The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid, several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Human FOLR1 shares 83% amino acid sequence identitiy with mouse and rat FOLR1. FOLR1 is up-regulated on many carcinomas, such as ovarian, and predominantly expressed on epithelial cells.
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Regulatory Status |
RUO – Research Use Only |
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