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Follistatin is an autocrine acting protein that is expressed by many tissues, but at noteably higher levels in the ovary and skin. Follistatin functions to negatively regulate the signaling of a wide variety of TGF-β family members (activin, BMPs, myostatin, GDF-11 and TGF-β1). Mechanistically, follistatin works as an antagonist by complexing with TGF-β family members to prevent them from interacting with their signaling receptors.
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Figure 2: 1µg in each lane (-) non-reducing conditions and (+) reducing conditions in a 4-20% TRIS-Glycine gel, stained with Coomassie Blue. Mouse Follistatin has a predicted MW of 31.6 kDa.
Figure 1: Mouse Follistatin Bioactivity Data. Serial dilutions of mouse Follistatin (starting at 1µg/ml) were mixed with 7.5ng/ml human Activin A, then added to MCP-11 cells. After 69 hours cell proliferation was measured and the linear portion of the curve was us used to calculate the ED50. The ED50 for this lot of mouse Follistatin was between 0.13-0.19µg/ml. This value is comparable to the typically expected to be less than 0.3µg/ml.
| Regulatory Status |
RUO – Research Use Only |
|---|
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| Alternative Name | FS, Activin-binding protein, FSH-suppressing protein |
|---|---|
| Purity | ≥95% (SDS-PAGE using Coomassie Staining) |
| Source | Produced in E. coli. Non-glycosylated protein, containing 289 amino acids. |