Home Shop Fn14 (mouse):Fc (human), (recombinant)

Fn14 (mouse):Fc (human), (recombinant)

ALX-522-036

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The fibroblast growth factor-inducible-14 (Fn14) is a 129 aa type Ia transmembrane protein. Fn14 is a growth-factor regulated, immediate-early response protein. It is expressed in a developmental and adult tissue-specific manner. Fn14 expression decreases cellular adhesion to extracellular matrix proteins fibronectin and vitronectin and reduces cell growth and migration. It is expressed at high levels in liver cancer cells, in hepatocellular carcinoma specimens as well as in regenerating liver cells showing Fn14 may play a role in hepatocyte growth and liver neoplasia. Fn14 has been described to bind TWEAK (Apo-3 Ligand), a member of the TNF family. Historical data has shown that Fn14 inhibits TWEAK-mediated killing of Kym-1 target cells.

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Product Details

Alternative Name	TWEAK-R, TNFRSF 12A, Fibroblast growth factor-inducible immediate-early response protein 14, CD266
Application Notes	ELISA: binds to TWEAK.
Concentration	1mg/ml after reconstitution.
Endotoxin Content	<0.1EU/µg purified protein (LAL test; BioWhittaker).
Formulation	Lyophilized. Contains PBS.
Gene/Protein Identifier	A003364 (UCSD Signaling Gateway ID)
MW	~34kDa (SDS-PAGE).
Purity	≥95% (SDS-PAGE)
Reconstitution	Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
Source	Produced in HEK 293 cells. The extracellular domain of mouse Fn14 (aa 1-75) is fused to the Fc portion of human IgG1.
Specificity	Binds human and mouse TWEAK.
UniProt ID	Q9CR75

Handling & Storage

Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

BAFF production by antigen-presenting cells provides T cell co-stimulation: B. Huard, et al.; Int. Immunol. 16, 467 (2004), Abstract
Potential role of APRIL as autocrine growth factor for megakaryocytopoiesis: D. Bonci, et al.; Blood 104, 3169 (2004), Abstract
TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor: T.C. Polek, et al.; J. Biol. Chem. 278, 32317 (2003), Abstract — Full Text

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Alternative Name	Thy-1 (RLE mutant)
Purity	≥90% (SDS-PAGE)
Source	Produced in HEK 293 cells. The extracellular domain of mutated hThy-1, hThy-1 (RLE) (aa 20-130), is fused to the Fc portion of human IgG1. The integrin binding sequence RLD of hThy-1 has been changed to RLE abolishing the binding of integrins.

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Fn14 (mouse):Fc (human), (recombinant)

ALX-522-036

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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