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Fluoxetine . HCl

BML-NS140

10 citations

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Potent and selective serotonin uptake inhibitor

Potent and selective serotonin uptake inhibitor. Clinically useful antidepressant.

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Product Details

Appearance	White crystalline powder.
CAS	56296-78-7
Formula	C₁₇H₁₈F₃NO . HCl
MW	345.8
Purity	≥98% (UHPLC)
Solubility	Soluble in water (4mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Lysosomal BK channels facilitate silica-induced inflammation in macrophages: Kendall, R. L., Holian, A., et al.; Inhal. Toxicol. 36, 31 (2024), Abstract
Cholesterol-dependent molecular mechanisms contribute to cationic amphiphilic drugs’ prevention of silica-induced inflammation: Kendall, R. L., Holian, A., et al.; Eur. J. Cell Biol. 102, 151310 (2023), Abstract
Loss of Adult 5-HT1A Autoreceptors Results in a Paradoxical Anxiogenic Response to Antidepressant Treatment: Turcotte-Cardin, V., Vahid-Ansari, F., et al.; J. Neurosci. 39, 1334 (2019), Abstract
The Serotonergic Raphe Promote Sleep in Zebrafish and Mice: Oikonomou, G., Altermatt, M., et al.; Neuron 103, 686 (2019), Abstract
Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior: Vahid-Ansari, F., Daigle, M., et al.; J. Neurosci. 37, 11967 (2017), Abstract
Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac): Y.G. Ni & R. Miledi; Proc. Natl. Acad. Sci. USA 94, 2036 (1997), Abstract — Full Text
Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication: D.T. Wong, et al.; Life Sci. 57, 411 (1995), Abstract
The interaction of antidepressant drugs with central and peripheral (enteric) 5-HT3 and 5-HT4 receptors: A. Lucchelli, et al.; Br. J. Pharmacol. 114, 1017 (1995), Abstract — Full Text
Binding of antidepressants to human brain receptors: focus on newer generation compounds: B. Cusack, et al.; Psychopharmacology (Berlin) 114, 559 (1994), Abstract
Facilitation of 5-hydroxytryptamine3 receptor desensitization by fluoxetine: P. Fan, et al.; Neuroscience 62, 515 (1994), Abstract

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Fluoxetine . HCl

BML-NS140

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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