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FLUOR DE LYS^® developer II concentrate

BML-KI176

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FLUOR DE LYS^® Developer II is an essential reagent for signal generation in assays done with the FLUOR DE LYS^®-HDAC8, FLUOR DE LYS^®-SIRT1 and FLUOR DE LYS^®-SIRT2 substrates. Deacetylation of the FLUOR DE LYS^® substrate sensitizes it so that, in a second step, treatment with the FLUOR DE LYS^® Developer II produces a fluorophore. Typically, an ‘inhibitor stop’ will be included in the 1x Developer dilution (e.g. nicotinamide for sirtuins).

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Product Details

Quantity	NOTE: This product is supplied packaged in 5 tubes (250 µl per tube) for a total volume of 1.25 ml. This packaging is used for optimal stability of the developer.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Protein kinase G inhibition preserves photoreceptor viability and function in a new mouse model for autosomal dominant retinitis pigmentosa: Zhu, Y., Peiroten, L., et al.; Cell Death Dis. 16, 575 (2025), Abstract
T-type voltage-gated channels, Na+/Ca2+-exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration: Yan, J., Wang, L., et al.; Cell Commun. Signal. 22, 92 (2024), Abstract
Protein kinase G inhibition preserves photoreceptor viability and function in a new mouse model for autosomal dominant retinitis pigmentosa: Zhu, Y., Peiroten, L., et al.; bioRxiv , (2024)
Inherited retinal degeneration: T-type voltage-gated channels, Na+/Ca2+-exchanger and calpain-2 promote photoreceptor cell death: Yan, J., Wang, L., et al.; bioRxiv , (2023)
Inherited Retinal Degeneration: Towards the Development of a Combination Therapy Targeting Histone Deacetylase, Poly (ADP-Ribose) Polymerase, and Calpain: Dong, Y., Yan, J., et al.; Biomolecules 13, (2023), Abstract
HDAC inhibition delays photoreceptor loss in Pde6b mutant mice of retinitis pigmentosa: insights from scRNA-seq and CUT&Tag: Dong, Y., Yan, J., et al.; PeerJ 11, e15659 (2023), Abstract
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism: Y. Huang, et al.; J. Biol. Chem. 297, 100929 (2021), Abstract
An optimized desuccinylase activity assay reveals a difference in desuccinylation activity between proliferative and differentiated cells: Yuan, T., Keijer, J., et al.; Sci. Rep. 10, 17030 (2020), Abstract
A Novel Flavonoid Glucoside from the Fruits of Lycium ruthenicun: J.J. Qi, et al.; Molecules 23, E325 (2018), Abstract — Full Text
Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition: K. King, et al.; Molecules 23, E321 (2018), Abstract — Full Text

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FLUOR DE LYS^® developer II concentrate

BML-KI176

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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FLUOR DE LYS® developer II concentrate

BML-KI176

Product Details

Handling & Storage

Related Products

FLUOR DE LYS® HDAC8 fluorometric drug discovery kit

BML-AK518

FLUOR DE LYS® SIRT1 fluorometric drug discovery assay kit

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FLUOR DE LYS® SIRT2 fluorometric drug discovery assay kit

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FLUOR DE LYS®-SIRT1 deacetylase substrate

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Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

FLUOR DE LYS^® developer II concentrate

FLUOR DE LYS^® HDAC8 fluorometric drug discovery kit

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FLUOR DE LYS^®-SIRT1 deacetylase substrate