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Benzodiazepine receptor ligand

Benzodiazepine antagonist. Reverses all the effects of benzodiazepine agonists and inverse agonists.

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Alternative Name	Ro 15-1788
Appearance	White crystalline powder.
CAS	78755-81-4
Couple Target	Benzodiazepine receptor
Couple Type	Ligand
Formula	C₁₅H₁₄FN₃O_3</sub
MW	303.3
Purity	≥98% (Assay)
Solubility	Soluble in ethanol (5 mg/ml warm) or DMSO (25 mg/ml warm)

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Reduction of reticulata neuronal activity by zolpidem and alpidem, two imidazopyridines with high affinity for type I benzodiazepine receptors: G. Mereu, et al.; Eur. J. Pharmacol. 179, 339 (1990), Abstract
Chronic treatment with Ro 15-1788 distinguishes between its benzodiazepine antagonist, agonist and inverse agonist properties: S. E. File, et al.; Neuropharmacol. 89, 113 (1986), Abstract

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