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CDK inhibitor
Potent inhibitor of cyclin-dependent kinases (CDKs). Induces apoptosis in certain tumor cells. Interacts with multidrug resistance protein 1 (MRP1).
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Product Details
| Alternative Name |
Alvocidib, (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one |
|---|---|
| Appearance |
Yellow powder. |
| CAS |
146426-40-6 |
| Couple Target |
CDK |
| Couple Type |
Inhibitor |
| Formula |
C21H20ClNO5 |
| Identity |
Identity determined by 1H-NMR. |
| MI |
14: 4094 |
| MW |
401.8 |
| Purity |
≥97% (HPLC) |
| Solubility |
Soluble in chloroform; slightly soluble in water. |
| Source |
Synthetic. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Long Term Storage |
+4°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- VEGFC/FLT4-induced cell-cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells: Jerafi-Vider, A., Bassi, I., et al.; Cell Rep. 35, 109255 (2021), Abstract
- VEGFC induced cell cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells: Jerafi-Vider, A., Moshe, N., et al.; bioRxiv , (2020)
- The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K: Słabicki, M., Kozicka, Z., et al.; Nature 585, 293 (2020), Abstract
- Neutrophil Extracellular Trap Formation Is Independent of De Novo Gene Expression: G. Sollberger, et al.; PLoS One 11, e0157454 (2016), Application(s): Inhibition, Abstract — Full Text
- Germline gain-of-function mutations in AFF4 cause a developmental syndrome functionally linking the super elongation complex and cohesin: K. Izumi, et al.; Nat. Genet. 47, 338 (2015), Application(s): Cell Culture, Abstract
- The structure and substrate specificity of human Cdk12/Cyclin K: Bösken, C. A., Farnung, L., et al.; Nat. Commun. 5, 3505 (2014), Abstract
- The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms: Natarajan, K., Bhullar, J., et al.; Biochem. Pharmacol. 85, 514 (2013), Abstract
- The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2: Sen, R., Natarajan, K., et al.; Mol. Cancer Ther. 11, 2033 (2012), Abstract
- Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen: Jester, B. W., Gaj, A., et al.; J. Med. Chem. 55, 1526 (2012), Abstract
- Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death: Josefsberg Ben-Yehoshua, L., Beider, K., et al.; PLoS One 7, e33856 (2012), Abstract
- Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors: C. Sekine, et al.; J. Immunol. 180, 1954 (2008), Abstract
- Flavopiridol synergizes TRAIL cytotoxicity by downregulation of FLIPL: T.E. Fandy, et al.; Cancer Chemother. Pharmacol. 60, 313 (2007), Abstract
- Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics: A. Pumrery, et al.; Curr. Pharm. Des. 12, 1949 (2006), Abstract
- Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells: U. Raju, et al.; Cancer Res. 63, 3263 (2003), Abstract — Full Text
- Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia: S. Kitada, et al.; Blood 96, 393 (2000), Abstract — Full Text
- Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials: A.M. Senderowicz; Invest. New Drugs 17, 313 (1999), (Review), Abstract
- Potent interaction of flavopiridol with MRP1: J.H. Hooijberg, et al.; Br. J. Cancer 81, 269 (1999), Abstract
- Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein: J.B. Schnier, et al.; FEBS Lett. 454, 100 (1999), Abstract
- Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53: J.C. Byrd, et al.; Blood 92, 3804 (1998), Abstract — Full Text
- Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells: S. Brüsselbach, et al.; Int. J. Cancer 77, 146 (1998), Abstract
- Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts: F. Arguello, et al.; Blood 91, 2482 (1998), Abstract — Full Text
- The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines: A. König, et al.; Blood 90, 4307 (1997), Abstract — Full Text
- Flavopiridol (L86-8275): selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells: M. Drees, et al.; Clin. Cancer Res. 3, 273 (1997), Abstract — Full Text
- Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase: W.F. Jr. De Azevedo, et al.; PNAS 93, 2735 (1996), Abstract — Full Text
- Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells: K.C. Bible & S.H. Kaufmann; Cancer Res. 56, 4856 (1996), Abstract — Full Text
- Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells: B.A. Carlson, et al.; Cancer Res. 56, 2973 (1996), Abstract — Full Text
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