Home Shop FKBP59 monoclonal antibody (KN382/EC1)

FKBP59 monoclonal antibody (KN382/EC1)

ADI-SRA-1400

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FKBP59, also known as Hsp56/p59 is an immunophilin that is a component of Hsp70/Hsp90/steroid receptor complexes. Expression of FKBP59 is increased in response to heat shock and ischemic stress, and is thought to play a role in the folding and cytoplasmic/nuclear distribution of steroid receptors.

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FKBP59 monoclonal antibody (KN382/EC1) Western blot — Western blot analysis of FKBP59 mAb (KN382/EC1) (Prod. No. ADI-SRA-1400): Lane 1: MW marker, Lane 2: HeLa Cell Lysate(heat shocked), Lane 3: MDBK Celll Lysate (heat shocked), Lane 4: VERO Cell Lysate (heat shocked), Lane 5: RK-13 Cell Lysate (heat shocked).

Product Details

Alternative Name	HSP56, Heat shock protein 56, FK506 binding protein 1A
Application	IHC, IP, WB
Application Notes	Detects a band of ~59kDa by Western blot.
Clone	KN382/EC1
Formulation	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
GenBank ID	M84474
Host	Mouse
Immunogen	Partially purified 9S rabbit uterine progesterone receptor.
Isotype	IgG1
Purity Detail	Protein G affinity purified.
Recommendation Dilutions/Conditions	Immunoprecipitation (10µg/ml)Western Blot (1:1,000, colorimetric)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from mouse ascites.
Species Reactivity	Bovine, Guinea pig, Hamster, Human, Mink, Monkey, Mouse, Rabbit
Technical Info / Product Notes	Recommended by the Human Protein Atlas Organization for IHC (Ensembl No. ENSG00000004478).
UniProt ID	P27124
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain: S. Tsutsumi, et al.; Nat. Struct. Mol. Biol. 16, 1141 (2009), Application(s): WB, IP using mouse cell lysates, Abstract
Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex: R. Voellmy, et al.; J. Biol. Chem. 276, 45791 (2001), Application(s): WB using human samples, Abstract
Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506: H.S. Gordon, et al.; J. Pharmacol. Exp. Ther. 289, 1202 (1999), Application(s): Other using human samples, Abstract