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Fis1 polyclonal antibody

ALX-210-1037

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The human Fis1, mitochondrial fission 1, is a novel molecule that was discovered as part of the mammalian fission machinery. Fis1 has been suggested to play a role in regulation of the fission processes that might be involved in apoptotic mechanisms.

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This antibody is covered by our Worry-Free Guarantee.

Fis1 polyclonal antibody Western blot — Western blot analysis of Fis1 pAb (Prod. No. ALX-210-1037) with Jurkat cell lysates.

Product Details

Alternative Name	Mitochondrial fission 1
Application	WB
Formulation	Liquid. In PBS containig 0.5% BSA, 0.01% thimerosal and 30% glycerol.
Host	Rabbit
Immunogen	Synthetic peptide surrounding aa 143 of human Fis1.
Isotype	IgG
Purity Detail	Affinity purified.
Recommendation Dilutions/Conditions	Western Blot (1-4 µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human, Mouse, Rat
UniProt ID	Q9Y3D6
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage: Verdejo, H. E., Parra, V., et al.; Cell Commun. Signal. 23, 256 (2025), Abstract
Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology.: Prudent, J., Khan, M., et al.; Cell. Mol. Life Sci. 79, 327 (2022), Application(s): WB, Abstract
The fasting-feeding metabolic transition regulates mitochondrial dynamics: M. Castro-Sepúlveda, et al.; FASEB J. 35, e21891 (2021), Abstract
Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease.: Gao, F., Krainc, D., et al.; Nat. Commun. 12, 1807 (2021), Application(s): WB / Reactant(s): Human, Abstract
FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62.: Hartikainen, P., Hiltunen, M., et al.; Mol. Neurobiol. 58, 5438 (2021), Application(s): WB, Abstract
Drp1 Tubulates the ER in a GTPase-Independent Manner.: Sesaki, H., Adachi, Y., et al.; Mol. Cell 80, 621 (2020), Application(s): WB, Abstract
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats: J.C.B. Ferreira, et al.; Nat. Commun. 10, 329 (2019), Abstract — Full Text
Fis1 deficiencies differentially affect mitochondrial quality in skeletal muscle: Z. Zhang, et al.; Mitochondrion 49, 217 (2019), Reactant(s) Mouse, Abstract — Full Text
Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission: Tsushima, K., Bugger, H., et al.; Circ. Res. 122, 58 (2018), Abstract
Advanced glycation end products receptor RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway: Y. Yu, et al.; Free Radic. Biol. Med. 112, 397 (2017), Application(s): Western Blot, Abstract

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Fis1 polyclonal antibody

ALX-210-1037

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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