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Finasteride

ALX-270-491

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5α-reductase inhibitor

Inhibitor of 5α-reductase, the enzyme which converts testosterone to the more potent androgen, 5α-dihydrotestosterone. Used as a treatment in benign prostatic hyperplasia and prostate cancer. Also used to treat male pattern hair loss.

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Product Details

Alternative Name	MK-906
Appearance	White to off-white crystalline powder.
CAS	98319-26-7
Couple Target	Reductase
Couple Type	Inhibitor
Formula	C₂₃H₃₆N₂O₂
Identity	Determined by IR.
MI	14: 4082
MW	372.5
Purity	≥98% (Assay (UV))
RTECS	CL5245000
Solubility	Soluble in DMSO, 100% ethanol, methanol or propanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures: Y. Ishihara, et al.; Steroids 113, 71 (2016), Application(s): Examination of the protective mechanism of progesterone against OGD/reoxygenation-induced neurotoxicity, Abstract
Finasteride for prostatic disease: an updated and comprehensive review: C. De Nunzio, et al.; Expert Opin. Drug Metab. Toxicol. 4, 1561 (2008), (Review), Abstract
Anti-nociceptive and anti-inflammatory properties of 5alpha-reductase inhibitor finasteride in experimental animals: D. Duborija-Kovacevic, et al.; Eur. J. Drug Metab. Pharmacokinet. 33, 181 (2008), Abstract
Finasteride induces apoptosis via Bcl-2, Bcl-xL, Bax and caspase-3 proteins in LNCaP human prostate cancer cell line: J.M. Golbano, et al.; Int. J. Oncol. 32, 919 (2008), Abstract
A new look at the 5alpha-reductase inhibitor finasteride: D.A. Finn, et al.; CNS Drug Rev. 12, 53 (2006), (Review), Abstract
Finasteride in the treatment of alopecia: J.F. Libecco & W.F. Bergfeld; Expert Opin. Pharmacother. 5, 933 (2004), (Review), Abstract
Finasteride: the first 5 alpha-reductase inhibitor: S.L. Sudduth & M.J. Koronkowski; Pharmacotherapy 13, 309 (1993), (Review), Abstract
Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding: G.H. Rasmusson, et al.; J. Med. Chem. 29, 2298 (1986), Abstract

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Finasteride

ALX-270-491

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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