H-Ficolin (Hakata antigen, Ficolin-3) is an innate immunity pattern recognition molecule found in human serum. H-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP) formed by carbohydrates (GlcNAc, GalNAc and fucose) activating complement through the lectin pathway by means of the associated MASPs ((MBL)-associated serine proteases). H-Ficolin consists of 35kDa protein chains associated in triplet subunits, which are again associated in high molecular weight oligomers by means of disulfide bonds at the N-terminal region.
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Regulatory Status |
RUO – Research Use Only |
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