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Fibroblast growth factors (FGFs) are a 22 member family of proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. Although the mechanism remains unclear, FGF-basic 154, also known as FGF-2, is a critical component in keeping embryonic stem cells undifferentiated in cell culture systems.
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Figure 1: Serial dilutions of Human FGF Basic 154, starting at 80 ng/mL, were added to NIH 3T3 cells. Cell proliferation was measured after 48 hours and the linear portion of the curve can be used to calculate the ED50.
| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Alternative Name | FGF2, HBGF-2, Prostatropin |
|---|---|
| Purity | ≥95% using Coomassie Staining |
| Source | Produced in E. coli. Non-glycosylated protein, containing 147 amino acids. |
| Alternative Name | FGF2, HBGF-2, Prostatropin |
|---|---|
| Purity | ≥95% (Reducing and Non-reducing SDS-PAGE) |
| Source | Produced in E. coli. Non-glycosylated protein, containing 145 amino acids. |
Last modified: May 29, 2024