Fibroblast growth factor 6 (FGF-6) is an important factor driving muscle differentiation and regeneration. FGF-6 is a heparin-binding growth factor that is expressed in epithelial and mesenchymal lineages. FGF-6 binds and signals through the FGF receptors FGFR1, FGFR2, and FGFR4. FGF-6 functions as a mitogen for vascular endothelial cells and fibroblasts.
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